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KMID : 0350519930460041593
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Journal of Catholic Medical College
1993 Volume.46 No. 4 p.1593 ~ p.1605
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Expression of Macrophage Colony-Stimulating Factor, Granulocyte Macrophage Colony-Stimulating Factor and Their Receptors in Ovarian Malignancies
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Abstract
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Coloy-stimulating factors(CSFs) are a family of glycoprotein that are involved in the survival, proliferation, differentiation and activation of hematopoietic cells at various stages of their development. The clinical ramification and therapeutic
evaluation of hematopoietic growth factors is a rapidly growing field that hods promise for the treatment of various medical illness.
Many nonhematopoietic tumors produce hematopoietkc growth factors that may influence cellular proliferation either by autocrine or by paracrine mechanism. So hematopoietic growth factors have been implicated in protean nonhematopoietic process.
In this study, expression of macrophage colony-stimulation factro(M-CSF), M0CSF receptor (M-CSF-R), granuocyte macrophage CSF (GF-CSF) and GM0CSF receptor (CM-CSF-R) was investigated in 37 gynecologic tissues including 31 samples of malignant
ovarian
tumor and 6 samples of benign ovarian tumor by RNA dot blot method. We systematically examined the relationship between the expression of CSFs and their receptors and clinical disease status.
@ES The results were as follows ;
@EN 1. In 31 ovarian malignancies, RNA expression of CSFs and their receptors was detected from 15 cases(48.4%) in M-CSF, 20 (64.5%) in M-CSF-R, 13(41.9%) in GM-CSF and 13(41.9%) in GM-CSF-R. Co-expression of M-CSF and M CSF-R was found in 13
cases
(41.9%) and that of GM-CSF and GM-CSF-R in 10 cases(30.3%). In 6 benign ovarian cysts, GM-CSF and GM-CSF-R expressions were not detected, but M-CSF-R expressions were detected in one case, even though at very low intensity.
2. CA125, the most significant tumor marker in ovarian cancer, was significantly elevated in the groups that expressed the M-CSF(P=0.047) and GM-CSF (P=0.045), but not in M-CSF-R and GM-CSF-R.
3. There were significantly high rates of RNA expression of RNA expression of M-CSF, M-CSF-R, GM-CSF and GM-CSF-R in poorly differentiated tumors (grade 3) compared with well and moderately differentiated tumors (P=0.001, P=0.035, P=0.003,
P=0.005,
respectively). By means of Mantel-Haenszel Chi-square analysis, the intensity of RNA expression also showed significant correlation with the histologic grades in M-CSF (P=0.005) and GM-CSF (P=0.041).
4. Age of patient, tumor size, pathologic diagnosis and FIGO stage did not show any significant relation with the expression of CSFs and their receptors.
This results indicate that hematopoietic growth factor modulate tumorigenesis by autocrine and paracrine mechanisms and the expression of hematopoietic growth factor and its receptor in ovarian malignancies could contribute to their proliferative
and
invasive characteristics in vivo.
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KEYWORD
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